9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 性质
| 沸点 | 519.7±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.092±0.06 g/cm3(Predicted) |
| 闪点 | -10 °C |
| 储存条件 | -20°C |
| 溶解度 | DMSO 中≥100 mg/mL，乙醇中≥100 mg/mL，DMF 中≥100 mg/mL，PBS pH 7.2 中≥2 mg/mL |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
| 形态 | 溶液在储存期间颜色可能会变暗 |
| 颜色 | 无色至浅黄 |
| BRN | 4267334 |
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 用途与合成方法
U-46619是一种PGH2类似物，可以用作血栓烷A2（TP）受体激动剂，影响人类血管平滑肌的促有丝分裂生长。U 46619是稳定的血栓烷A2模拟物，是H2内过氧化物前列腺素的类似物，用作血管收缩剂和血栓烷受体激动剂。
U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的血栓素 A2 (TXA2) 的类似物，也是一种有效的 TXA2 激动剂。TXA2
U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC
50
s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.
U-46619 (10 nM-10 μM) increases internal Ca
2+
concentration ([Ca
2+
]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.
U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).
| Animal Model: | 12-15 weeks-old male and female SHR |
| Dosage: | 5 μg/kg |
| Administration: | Intravenous injection |
| Result: | Induceed a significant increase of MABP after 1 min in male SHR. |
安全信息
| 危险品标志 | F,Xi |
|---|---|
| 危险类别码 | 11-36-66-67 |
| 安全说明 | 16-26 |
| 危险品运输编号 | UN 1231 3/PG 2 |
| WGK Germany | 2 |
| RTECS号 | MJ9681090 |
| F | 8-10-23 |
| 毒性 | LD50 intravenous in mouse: 66ug/kg |
9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-108566 | 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 | 56985-40-1 | 1mg(28.5mM * 100μL in Methyl acetate) | 3300 |
| 2024-08-19 | HY-108566 | 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 | 56985-40-1 | 5mg(28.5mM * 500μL in Methyl acetate) | 9900 |
