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4-Bromomethyl-7-methoxycoumarin

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4-Bromomethyl-7-methoxycoumarin Basic information
4-Bromomethyl-7-methoxycoumarin Chemical Properties
  • Melting point:213-215 °C (lit.)
  • Boiling point:385.3±42.0 °C(Predicted)
  • Density 1.552±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • solubility chloroform: soluble20mg/mL, clear, colorless to faintly yellow
  • form Powder and/or Chunks
  • color Off-white to light yellow or beige
  • Water Solubility insoluble
  • λmax330 nm (MeOH)
  • BRN 187211
  • Stability:Stable, but moisture and light-sensitive. Combustible. Incompatible with strong oxidizing agents.
  • Major ApplicationDetection of nitrated explosives; measuring ultraviolet ray power; photoacid generators; polyurethane foams; photoresists silica nanoparticles
  • Biological ApplicationsAnalyzing/detecting carboxylic acids;analyzing/labeling fatty acids; detecting nitric oxide; detecting/separating bile acids; labeling pyrimidine nucleobases; anticancer agents; biomedical trace analysis; herbicides; as a substrate for measuring histone acetyltransferases (HATs) activity, peptidases activity, sirtuin activity
  • CAS DataBase Reference35231-44-8(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-22
  • Safety Statements 26-36-37/39
  • RIDADR 1759
  • WGK Germany 3
  • HazardClass 8
  • PackingGroup III
  • HS Code 29322090
MSDS
4-Bromomethyl-7-methoxycoumarin Usage And Synthesis
  • Chemical PropertiesLight Green-Yellow Crystals
  • Uses4-Bromomethyl-7-methoxycoumarin can be used as fluorescent label for fatty acids. For derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.
  • UsesUsed for derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2
  • Uses
    4-Bromomethyl-7-methoxycoumarin has been used:
    • as derivatization reagent in determination of 5-fluorouracil (5-FU) in human plasma by HPLC-tandem mass spectrometry
    • as derivatization reagent in fluorescence detection of sodium monofluoroacetate (MFA-Na) in biological samples by HPLC
    • in the synthesis of new caged derivatives of hydrolysis-resistant 8-bromoadenosine cyclic 3′,5′-monophosphate (8-Br-cAMP) and 8-bromoguanosine cyclic 3′,5′-monophosphate (8-Br-cGMP)
    • in TLC and HPLC separation and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2
  • Purification MethodsThe coumarin crystallises from boiling AcOH; the crystals are washed with AcOH, EtOH and dried in a vacuum; 1HNMR (TFA) 3.97s, 4.57s, 6.62s, 6.92-7.19m and 7.80d. [Secrist et al. Biochem Biophys Res Commun 45 1262 1971, Dünges Anal Chem 49 442 1977, Beilstein 18 III/IV 348.]
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