CPD1578
CPD1578 性质
| 密度 | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 氯仿：5mg/mL； DMF：0.2mg/mL； DMSO：0.2mg/mL；乙醇：微溶 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.41±0.50(Predicted) |
| 颜色 | 白色至米白色 |
| InChI | InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19) |
| InChIKey | HNKGGVGQAVODNJ-UHFFFAOYSA-N |
| SMILES | C12=C(C(N)=O)C=NN1C(C1=CC=CC(C)=C1)=CC=N2 |
CPD1578 用途与合成方法
|
TLR8 67 nM (IC 50 ) |
CU-CPT-8m is a specific TLR8 antagonist, with an IC 50 of 67±10 nM and negligible cytotoxicity. The K d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC 50 of 90±10 nM, which is in good agreement with its IC 50 value determined in HEK-Blue TLR8 cells.
CPD1578 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-112050 | 1 mg | 502 | ||
| 2024-11-08 | HY-112050 | CPD1578 | 125079-83-6 | 5mg | 1000 |
