CATHARANTHINE TARTRATE

Chemical Properties

Melting point	145-1470C
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
form	White to off-white crystalline powder.
color	White to Pale Beige
InChIKey	JYBKPXVXYJDIFX-GYMDHWDQSA-N
SMILES	[C@]12(C(OC)=O)[C@]3(C(=C[C@]([H])(CN3CCC3C4=C(C=CC=C4)NC1=3)C2)CC)[H].C(O)(C(O)=O)C(O)C(O)=O

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Animal Model:	13-week-old male SpragueDawley rats (300-350 g)^[1]
Dosage:	0.5-20 mg/kg
Administration:	IV; single dose
Result:	Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.