ChemicalBook Product Catalog API Nervous system drugs Drug Metabolism in Human Brain Atabecestat

Atabecestat

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Animal Model:	5-week-old APPPS1 mice^[2]
Dosage:	100 and 300 mg/kg
Administration:	Oral gavage; 100 and 300 mg/kg; once daily for 3 days
Result:	Reduced the level of human Aβ_1-40 and Aβ_1-42 levels in the brain of APPPS1 mice at a dose of 300 mg/kg and resulted in less reduction of human Aβ levels at 24 h with a dose of 100 mg/kg.