(±)9-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 9(S)-HEPE and 9(R)-HEPE. The biological activity of (±)9-HEPE has not been clearly documented.
9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo[1].
ChEBI: 9-HEPE is a HEPE that is (5Z,7E,11Z,14Z,17Z)-icosapentaenoic acid carrying a hydroxy substituent at position 9. It has a role as a marine metabolite. It is a conjugate acid of a 9-HEPE(1-).
[1] Hidetoshi Yamada, et al. Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. J Lipid Res. 2014 May;55(5):895-904. DOI:
10.1194/jlr.M047514
