4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
in vivo
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].
IC 50
eIF4
References
[1] Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. DOI:10.1128/JVI.00078-11