Aminooxy-PEG2-alcohol

Product NameAminooxy-PEG2-alcohol
CAS185022-12-2
MFC4H11NO3
MW121.14
EINECS
MOL File185022-12-2.mol

Chemical Properties

Boiling point	265.9±20.0 °C(Predicted)
Density	1.116±0.06 g/cm3(Predicted)
pka	14.39±0.10(Predicted)

Usage And Synthesis

Description

Aminooxy-PEG2-alcohol is a short PEG linker containing an aminooxy group and a a hydroxyl group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c