Azido-PEG5-acid

Product NameAzido-PEG5-acid
CAS1425973-16-5
MFC13H25N3O7
MW335.36
EINECS
MOL File1425973-16-5.mol

Chemical Properties

storage temp.	Storage temp. 2-8°C
solubility	Soluble in Water
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

Azido-PEG5-acid is a water soluble PEG linker. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Azido-PEG3-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize PROTAC molecules. Also Azido-PEG3-acid is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target