Bromo-PEG4-azide is a bifunctional crosslinker containing a bromide and a terminal azide. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a good leaving group for nucleophilic substitution. The azide(N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry.
Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
