White or almost white or light beige crystal or crystalline powder, odorless, slightly bitter taste. Soluble in hot water, insoluble in water or ethanol. Melting point 233-234℃(decomposition), melting point 237-239℃. (+)-configuration (Dexrazoxane): [24584-09-6]. Crystallized from aqueous methanol-ether, melting point 193 °C. [α]D+11.35° (C=5, dimethylformamide). Solubility (mg/ml): 10-12 (water), 35-43 (0.1 mol/L hydrochloric acid), 25-34 (0.1 mol/L sodium hydroxide), 6.7-10 (10% ethanol), 1 (methanol), 7.1-10 [water-dimethylformamide (1:1)], 9.7-14.5 [0.1 mol/L citrate buffer (Ph 4) ], 8.7 to 13 [0.1 mol/L boric acid buffer (Ph 9)].
Suspected carcinogen
with experimental carcinogenic and
tumorigenic data. Moderately toxic by
intraperitoneal route. Experimental
teratogenic and reproductive effects. Human
systemic effects by ingestion: nausea,
thrombocytopenia, leukopenia. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx.
