UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.
um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34+CD15- Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists.
In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution.
