安乃近杂质C
安乃近杂质C 性质
| 熔点 | >195°C |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于氯仿（轻微，超声处理）、DMSO（轻微）、水（轻微） |
| 形态 | 固体 |
| 颜色 | 浅橙色至浅棕色 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C12H15N3O.ClH/c1-9-11(13-2)12(16)15(14(9)3)10-7-5-4-6-8-10;/h4-8,13H,1-3H3;1H |
| InChIKey | NNONRTWOIVTAHL-UHFFFAOYSA-N |
| SMILES | O=C1C(NC)=C(C)N(C)N1C2=CC=CC=C2.[H]Cl |
安乃近杂质C 用途与合成方法
COX
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.
安乃近杂质C 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-135731A | 安乃近杂质C | 856307-27-2 | 100mg | 2450 |
| 2024-01-25 | HY-135731A | 安乃近杂质C | 856307-27-2 | 25mg | 1050 |
