H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo[1].
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats[1].
| Animal Model: | Anesthetized male SpragueDawley rats[1] |
| Dosage: | 12.5 mg/kg |
| Administration: | Intraarterial injection; 12.5 mg/kg once |
| Result: | Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.
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| Animal Model: | Spontaneously hypertensive rats[1] |
| Dosage: | 0, 50 and 100 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.
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