6-Bromo-1H-pyrazolo[4,3-c]pyridine

1H-Pyrazolo[4,3-c]pyridine, 6-broMo- is commonly used in proteomics and chemical research.

6-Bromo-1H-pyrazolo[4,3-c]pyridine is a key synthetic building block that can be used to construct a variety of N1-substituted pyrazolo[4,3-c]pyridine frameworks. The bromine atom at the 6-position in its structure can participate in both copper-catalysed cross-coupling reactions and N-alkylation reactions with halogenated alkanes under basic conditions. These intermediates can also be utilised in the synthesis of PLK4 inhibitors via reactions such as palladium-catalysed C–H activation and nitro reduction[1].

[1] Jeong*, J. W., Chang, T., and, Murray, J. M. (2025). Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4. Journal of Medicinal Chemistry, 68 23, 25198–25212. https://doi.org/10.1021/acs.jmedchem.5c02200