PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt)

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) (Item No. 64920) by GC- or LC-MS.. The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.3,4 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see references 5 and 6.WARNING This product is not for human or veterinary use.

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[2] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI: 10.1146/annurev.bi.61.070192.001301
[3] KENICHI TANAKA. A Target of Phosphatidylinositol 3,4,5-Trisphosphate with a Zinc Finger Motif Similar to that of the ADP-Ribosylation-Factor GTPase-Activating Protein and Two Pleckstrin Homology Domains[J]. The FEBS journal, 2004, 245 2: 512-519. DOI: 10.1111/j.1432-1033.1997.00512.x
[4] X YANG. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.[J]. The Journal of Biological Chemistry, 1999, 274 27: 18973-18980. DOI: 10.1074/jbc.274.27.18973
[5] L J PIKE  L C. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains.[J]. The Journal of Biological Chemistry, 1996, 271 43: 26453-26456. DOI: 10.1074/jbc.271.43.26453
[6] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI: 10.1038/361315a0