Cl-amidine is an orally active PAD inhibitor with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4, respectively.It induces apoptosis in cancer cells. And Cl-Amidine blocks histone 3 citrullination and neutrophil extracellular trap formation and improves survival in mice with sepsis.
