(1-pentyl-1H-indol-3-yl) (2, 2, 3, 3-tetraMethyl-cyclopropyl) Methanone

UR-144 (Item No. ISO00055) is an analytical reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends. UR-144 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

(1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone is an Indol-3-ylcycloalkyl Ketone with high affinity for the CB2 cannabinoid receptor. Tetramethylcyclopropyl group was found to lead to high affinity CB2 agonists. Synthetic Cannabinoids

[1] JENNIFER M. FROST*. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity[J]. Journal of Medicinal Chemistry, 2009, 53 1: 295-315. DOI: 10.1021/jm901214q
[2] KATHRYN A. SEELY . Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds[J]. Forensic science international, 2013, 233 1: Pages 416-422. DOI: 10.1016/j.forsciint.2013.10.002
[3] BYUNGSUK CHO . Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair[J]. Forensic science international, 2020, 306: Article 110058. DOI: 10.1016/j.forsciint.2019.110058
[4] THOMAS B, LEFEVER T, CORTES R A, et al. Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences[J]. The Journal of Pharmacology and Experimental Therapeutics, 2017, 9 1: 0. DOI: 10.1124/jpet.116.238717