2'-Bromo-4-chloro-biphenyl

583-55-1

1679-18-1

179526-95-5

1-Bromo-2-iodobenzene (30 g, 106 mmol) and 4-chlorophenylboronic acid (16.9 g, 108.6 mmol) were added to an aqueous 2M potassium carbonate solution (100 ml) in dioxane solution. Subsequently, tetrakis(triphenylphosphine)palladium (2.45 g, 2 mol%) was added as a catalyst. The reaction mixture was heated and reacted under stirring for 4 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with potassium carbonate solution followed by separation of the aqueous and organic layers. After the organic layer was concentrated under reduced pressure to remove the solvent, it was purified by column chromatography (eluent: hexane) to afford the target product 2-bromo-4'-chloro-1,1'-biphenyl (A1) as a white solid (25.3 g, 90% yield).