CP-154526 Hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) (1,2,3). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF and displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
CP-154526 is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1).
CP 154526 (1-10 mg/kg; i.p.; once) hydrochloride exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2].
| Animal Model: | Male Sprague Dawley rats[2] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | i.p.; once |
| Result: | Exhibited signs of anxiolytic-like activity. |
