2-(Trifluoromethyl)benzamide

312-94-7

360-64-5

The general procedure for the synthesis of 2-(trifluoromethyl)benzamide from 2-(trifluoromethyl)benzoyl chloride is as follows: 2-(trifluoromethyl)benzoyl chloride (50 g) was added to a reaction vessel with isopropanol (400 g) and ammonia was passed into it. The reaction mixture was stirred at a temperature range of -10°C to 0°C for 3.5 hours to facilitate the reaction. Upon completion of the reaction, ammonium chloride precipitated as a precipitate and the reaction mixture was separated by filtration to obtain a filtrate. Subsequently, the filtrate was concentrated to obtain the final target product 2-(trifluoromethyl)benzamide (compound of formula I). The yield of this synthesis step was 90% and the purity of the product (as determined by HPLC) was 99%.