Potent, selective 5-HT4 serotonin receptor agonist. New ester of 4-Amino-5-chloro-2-methoxybenzoic acid as potent agonist and antagonist for 5-HT4 receptors.
in vivo
ML 10302 hydrochloride (20mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice[3].
Animal Model:
8-weeks old adult male C57BL/6j wild-type mice (23-27g)[3]
Dosage:
5 mg/kg, 10 mg/kg, 20mg/kg
Administration:
Subcutaneous injection
Result:
Significantly increased sAPPα level in the cortex.
