STAT6 is a transcription factor and member of the STAT protein family with roles in innate and adaptive immunity.1,2 It is composed of N-terminal, coiled-coil, DNA-binding, and linker domains that mediate nuclear translocation and export, as well as Src homology 2 (SH2) and C-terminal transactivation domains that are subject to phosphorylation.2 Phosphorylation of STAT6 at tyrosine 641 (Tyr641) is mediated by JAKs in response to stimulation with cytokines or growth factors and induces STAT6 dimerization and nuclear translocation, leading to STAT6-dependent gene transcription.3,1 STAT6 is necessary for STING-induced immune responses to viral infection in vitro and in vivo.4 The levels of phosphorylated STAT6 are increased in thyroid epithelial cells isolated from patients with Grave's disease.5 Cayman's STAT6 Rabbit Monoclonal Antibody (Clone RM473) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
