TRPV1-Tat (trifluoroacetate salt)

TRPV1-Tat is a peptide antagonist of transient receptor potential vanilloid 1 (TRPV1).1 It consists of amino acids 736-745 from the A-kinase anchor protein (AKAP)-binding domain of TRPV1 and the cell-penetrating peptide sequence from HIV Tat. TRPV1-Tat (200 µM) inhibits currents induced by heat or phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in whole-cell patch-clamp assays using primary mouse dorsal root ganglia. It increases the hind paw mechanical pain threshold in rats when administered at the doses 10 or 30 µM.2WARNING This product is not for human or veterinary use.

[1] MICHAEL J M FISCHER P A M Joan Btesh. Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia.[J]. Journal of Neuroscience, 2013, 33 17: 7407-7414. DOI: 10.1523/jneurosci.3721-12.2013
[2] MAN-KYO CHUNG. Peripheral Group I Metabotropic Glutamate Receptor Activation Leads to Muscle Mechanical Hyperalgesia Through TRPV1 Phosphorylation in the Rat[J]. Journal of Pain, 2015, 16 1: Pages 67-76. DOI: 10.1016/j.jpain.2014.10.008