Myr-Tat-CBD3 (trifluoroacetate salt)

Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2).1 It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons (IC50 = ~2.8 µM). Myr-Tat-CBD3 (20 µM) inhibits calcium, but not sodium, currents in primary DRG neurons. Intrathecal administration of myr-Tat-CBD3 (20 µg/5 µl) prevents carrageenan-induced decreases in paw withdrawal latencies in rats. Myr-Tat-CBD3 decreases cue-induced reinstatement of cocaine-seeking behavior in rats.2WARNING This product is not for human or veterinary use.

[1] LIBERTY FRANÇOIS-MOUTAL. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.[J]. PAIN®, 2015, 156 7: 1247-1264. DOI: 10.1097/j.pain.0000000000000147
[2] WILLIAM C BUCHTA. Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.[J]. Molecular Neurobiology, 2020, 57 1: 346-357. DOI: 10.1007/s12035-019-01711-9