Tertiapin LQ (trifluoroacetate salt)

Tertiapin LQ is a peptide derivative of the honeybee venom peptide tertiapin and an inhibitor of inwardly rectifying potassium (Kir) channels.1,2 It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as Kir3.1 and Kir3.4, respectively, as well as the inward-rectifier potassium channel 1 (Kir1.1). In vivo, tertiapin LQ suppresses the Purkinje cell pause response to a conditional stimulus in ferrets. 2WARNING This product is not for human or veterinary use.

[1] W. YE. The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction[J]. Proceedings of the National Academy of Sciences, 2015, 140 26 1: E229-E238. DOI: 10.1073/pnas.1514282112
[2] FREDRIK JOHANSSON  Germund H. Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses.[J]. Scientific Reports, 2020: 15654. DOI: 10.1038/s41598-020-72581-8