N1-(tert-butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide

Chemical Properties

Boiling point	425.3±38.0 °C(Predicted)
Density	1.22±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL, clear
form	powder
pka	7.77±0.40(Predicted)
color	white to light brown
InChI	1S/C12H17N3O2S/c1-12(2,3)14-11(18)15-13-7-8-4-5-9(16)6-10(8)17/h4-7,16-17H,1-3H3,(H2,14,15,18)/b13-7+
InChIKey	LTFUAYRGVLQXKC-NTUHNPAUSA-N
SMILES	S=C(N\N=C\c1c(cc(cc1)O)O)NC(C)(C)C

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Animal Model:	Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells^[1]
Dosage:	5 mg/kg, 25 mg/kg
Administration:	i.v.; 2 times a week; for 3 weeks
Result:	Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.