A pyrrolizidine alkaloid which is found in Senecio Jacobea, this base has [α]20D +
48° (CHC13 ) and is hydrolyzed by alkalies to retronecine and jacolinecic acid,
ClOH1S0 7. The latter contains three hydroxyl and three methyl groups.
Jacoline is a potentially carcinogenic, mutagenic, and teratogenic hepatotoxic alkaloid found in the nectar of tansy ragwort (S. jacobaea).
Bradbury, Culvenor., Chern. & Ind., 1021 (1954)
Bradbury, Culvenor., Austral. J. Chern., 7,378 (1954)
Bradbury, Willis., ibid, 9,258 (1956)
Geissman" ibid, 12,247 (1959)
