三甲胺N-氧化物
三甲胺N-氧化物 性质
| 熔点 | 220-222 °C (lit.) |
|---|---|
| 沸点 | 133.8°C (rough estimate) |
| 密度 | 0.9301 (rough estimate) |
| 蒸气压 | 23.5Pa at 20℃ |
| 折射率 | 1.4698 (estimate) |
| FEMA | 4245 | TRIMETHYLAMINE OXIDE |
| 储存条件 | Hygroscopic, Room Temperature, under inert atmosphere |
| 溶解度 | 可溶于氯仿、DMSO、甲醇（微溶） |
| 酸度系数(pKa) | 4.65(at 25℃) |
| 形态 | 固体 |
| 颜色 | 淡黄色低 |
| 气味 (Odor) | 无味 |
| 水溶解性 | 793g/L at 24.5℃ |
| JECFA Number | 1614 |
| Merck | 14,9711 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C3H9NO/c1-4(2,3)5/h1-3H3 |
| InChIKey | UYPYRKYUKCHHIB-UHFFFAOYSA-N |
| SMILES | C[N+](C)(C)[O-] |
| LogP | -2.79 |
| EPA化学物质信息 | Methanamine, N,N-dimethyl-, N-oxide (1184-78-7) |
三甲胺N-氧化物 用途与合成方法
ROS/NLRP3 inflammasome
TGF-β/smad2
The size and migration of fibroblasts are increased after Trimethylamine N-oxide (TMAO) treatment compared with non-treated fibroblasts in vitro. Trimethylamine N-oxide increases TGF-β receptor I expression, which promotes the phosphorylation of Smad2 and up-regulates the expression of α-SMA and collagen I. The ubiquitination of TGF-βRI is decreased in neonatal mouse fibroblasts after Trimethylamine N-oxide treatment. Trimethylamine N-oxide also inhibits the expression of smurf2.
Trimethylamine N-oxide is frequently found in the tissues of a variety of marine organisms that protects against the adverse effects of temperature, salinity, high urea and hydrostatic pressure.
Trimethylamine N-oxide (TMAO) contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet.
将100ml三甲胺水溶液与600ml过氧化氢溶液相混合，在室温放置24h后，如果还有胺的气味，就再加100～200ml的过氧化氢溶液，当所有胺均被氧化后，在减压下蒸发至干。残余物用乙醇-乙醚混合物重结晶。得二水合氧化三甲胺，为长针状晶体，产率95%。
在油浴中减压至1.33～1.6kpa并加热到120℃，慢慢地升温至150℃，当水分被驱除后，升温至180℃～200℃，纯的无水氧化三甲胺即升华在瓶子较冷的颈部。
另一种脱水法：将45.0g二水合氧化三甲胺溶于300ml热DMF中，盛于圆底烧瓶中进行蒸馏。先在常压下加热以蒸去溶剂，直到沸点达到152～153℃。然后用水泵减压以除去残留的溶剂。蒸馏的末了将油浴的温度慢慢地升至120℃。剩下的无水氧化三甲胺重30g.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| 海关编码 | 2904.20.5000 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 吸入 急性毒性 类别4 经口 |
三甲胺N-氧化物 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-116084R | 三甲胺N-氧化物 | 1184-78-7 | 10 mg | 300 |
| 2026-09-15 | HY-116084R | 三甲胺N-氧化物 | 1184-78-7 | 25 mg | 530 |
