4-Amino-6-chloropyrimidine-5-carbaldehyde

Yellow solid

4-Amino-6-chloropyrimidine-5-carbaldehyde is an important pharmaceutical intermediate compound that can be used in the preparation of ENPP1 inhibitors [1]. Furthermore, it serves as a key starting material for the synthesis of novel 4-amino-pyrimidine-5-formyl oxime VEGFR-2 inhibitors [2].

[1] Sun, Y., Chen, M., Han, Y. (2024). Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of Medicinal Chemistry, 67 5, 3986–4006. https://doi.org/10.1021/acs.jmedchem.3c02288
[2] Huang, S., Li, R., LaMontagne, K. R., Greenberger, L. M., & Connolly, P. J. (2011). 4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II. Bioorganic & Medicinal Chemistry Letters, 21 6, Pages 1815-1818. https://doi.org/10.1016/j.bmcl.2011.01.053