S-4-bromobenzylglutathione cyclopentyl diester
S-4-bromobenzylglutathione cyclopentyl diester
英文名称:S-4-bromobenzylglutathione cyclopentyl diester
CAS号:166038-00-2
分子式:C27H38BrN3O6S
分子量:612.58
EINECS号:
Mol文件:166038-00-2.mol
S-4-bromobenzylglutathione cyclopentyl diester 性质
| 沸点 | 790.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（408.11 mM） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.84±0.46(Predicted) |
| 颜色 | 白色至米色 |
| InChIKey | QIFSPGPRHFNZNN-GOTSBHOMSA-N |
| SMILES | BrC1=CC=C(CSC[C@H](NC(CC[C@H](N)C(OC2CCCC2)=O)=O)C(NCC(OC3CCCC3)=O)=O)C=C1 |
S-4-bromobenzylglutathione cyclopentyl diester 用途与合成方法
BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制剂，其 GC50 为 4.23 μM (HL-60 细胞)。BrBzGCp2 具有抗肿瘤和神经保护活性。
GC50: 4.23 μM (GLO1).
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior.
BrBzGCp2 pre-treatment decreases seizure duration.
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA
A
receptor activation.
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.
| Animal Model: | Male CD-1 mice. |
| Dosage: | 50 mg/kg. |
| Administration: | IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) |
| Result: | Allowed MG levels to accumulate for 2 hours |
S-4-bromobenzylglutathione cyclopentyl diester 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester | 166038-00-2 | 5mg | 800 |
| 2026-09-15 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester | 166038-00-2 | 10mM * 1mLin DMSO | 1078 |
S-4-bromobenzylglutathione cyclopentyl diester供应商 更多
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话：021-61415566 800-8193336
产品介绍：
英文名称：S-p-Bromobenzylglutathione cyclopentyl diester
CAS：166038-00-2
纯度：>=98% (HPLC)
包装信息：5mg, 25mg
备注：SML1306
安耐吉化学&3A（安徽泽升科技股份有限公司）
联系电话：400-0056266
产品介绍：
中文名称：S-p-溴苄基谷胱甘肽环戊基二酯
英文名称：S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
CAS：166038-00-2
纯度：98% (HPLC)
包装信息：25mg;5mg
备注：NULL
天津普西唐生物医药科技有限公司
联系电话：010-60605840
产品介绍：
英文名称：BrBzGCp2
CAS：166038-00-2
纯度：>=98%
包装信息：100mg;10mg;5mg;50mg;25mg
TargetMol中国（陶术生物）
联系电话：4008200310 15002144251
产品介绍：
中文名称：化合物 BrBzGCp2
英文名称：BrBzGCp2
CAS：166038-00-2
纯度：98.68%
包装信息：2mg/RMB 499
