EZATIOSTAT游离的
EZATIOSTAT游离的 性质
| 熔点 | >94°C (dec.) |
|---|---|
| 沸点 | 749.7±60.0 °C(Predicted) |
| 密度 | 1.216±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12+-.0.46(Predicted) |
| 颜色 | 白色至类白色 |
| InChIKey | FXTMNDVNPLUYKX-OKIYALLLNA-N |
| SMILES | C(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r| |
EZATIOSTAT游离的 用途与合成方法
| Target | Value |
|
GSTP1-1
() | |
|
JNK1
() | |
|
ERK1/ERK2
() |
Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone.
Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allowes the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.
Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1 +/+ ) and not in GSTP1 -/- animals.
EZATIOSTAT游离的 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | S9698 | EZATIOSTAT游离的 | 168682-53-9 | 5mg | 795.31 |
| 2026-03-03 | S9698 | EZATIOSTAT游离的 | 168682-53-9 | 10mM (1mL in DMSO) | 958.23 |
