11β-羟基雄甾-4-烯-3,17-二酮
11β-羟基雄甾-4-烯-3,17-二酮
11β-羟基雄甾-4-烯-3,17-二酮 性质
| 熔点 | 197-199℃ |
|---|---|
| 沸点 | 475.3±45.0 °C(Predicted) |
| 密度 | 1.19±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（826.69 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 14.49±0.60(Predicted) |
| 颜色 | 白色至米白色 |
| InChI | InChI=1S/C19H26O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-15,17,21H,3-8,10H2,1-2H3/t13-,14-,15-,17+,18-,19-/m0/s1 |
| InChIKey | WSCUHXPGYUMQEX-KCZNZURUSA-N |
| SMILES | C1[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]2(C)[C@@]3([H])CCC2=O)=CC(=O)C1 |
11β-羟基雄甾-4-烯-3,17-二酮 用途与合成方法
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Human Endogenous Metabolite
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In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.
11β-羟基雄甾-4-烯-3,17-二酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-05-22 | HY-114464 | 4-雄烯-11β-醇-3,17-二酮 | 382-44-5 | 5mg | 400 |
| 2025-05-22 | HY-114464 | 4-雄烯-11β-醇-3,17-二酮 | 382-44-5 | 10mM * 1mLin DMSO | 440 |
