IONIS-PKK-LRX)

Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).

[1] Fijen LM, Riedl MA, Bordone L, et al. Inhibition of Prekallikrein for Hereditary Angioedema.?N Engl J Med. 2022;386(11):1026-1033. DOI:10.1056/NEJMoa2109329
[2] Valerieva A, Longhurst HJ. Treatment of hereditary angioedema-single or multiple pathways to the rescue.?Front Allergy. 2022;3:952233. DOI:10.3389/falgy.2022.952233