questin

Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 μg/mL, 62.5 μg/mL, 62.5 μg/mL, and 125 μg/mL[1].

ChEBI: Questin is a dihydroxyanthraquinone that is 1,6-dihyroxy-9,10-anthraquinone which is substituted by a methyl group at position 3 and a methoxy group at position 8. It is functionally related to an emodin. It is a conjugate acid of a questin-2-olate.

[1] Lei Guo, et al. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi. 3 Biotech. 2017 Dec;7(6):383. DOI:10.1007/s13205-017-1015-z
[2] SUNG-GYU CHOI. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.[J]. Natural Product Research, 2007, 21 6: 487-493. DOI: 10.1080/14786410601012265
[3] THIERRY GAUTHIER. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells.[J]. PLoS ONE, 2012: e29906. DOI: 10.1371/journal.pone.0029906
[4] NIANZHEN LIU . Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301[J]. Fitoterapia, 2019, 135: Pages 27-32. DOI: 10.1016/j.fitote.2019.03.031
[5] NIRMALK. CHAUDHARY. Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus[J]. Journal of Natural Products , 2018, 81 7: 1517-1526. DOI: 10.1021/acs.jnatprod.7b00816