2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-

Product Name2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
CAS106392-48-7
MFC16H20N2O2
MW272.34
EINECS
MOL File106392-48-7.mol

Chemical Properties

Boiling point	468.4±45.0 °C(Predicted)
Density	1.137±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO : ≥ 110 mg/mL (403.91 mM)
pka	10.05±0.40(Predicted)
form	Solid
color	Light yellow to yellow

Usage And Synthesis

Biological Activity

ST271 is a tyrosine phosphorylation inhibitor that inhibits phospholipase D activity.

in vitro

ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30% ) but significant inhibition of the response to thrombin and U46619.

target

Preparation Products And Raw materials

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Target	Value
PLD ()