Skleronorm,Gruenenthal,W. Germany,1977
Derivative of thyroxine. Antilipemic.
ChEBI: Etiroxate is an aromatic ether.
7.91 g of α-methyl thyroxine are suspended in 150 cc of ethanol. While
heating, the solution is saturated with dry hydrogen chloride. Thereafter, the
solvent is distilled off at reduced pressure. The residue is dissolved in a
mixture of ethanol and water (1:1). Adding a 5% solution of sodium hydrogen
carbonate in water, the ethyl ester of α-methyl thyroxine precipitates; melting
point: 156°C to 157°C after recrystallization from ethanol. The yield is 6.05 g,
i.e., 74% of the theoretical yield.
