Chrysanthemum Indicum Extract is extracted from Chrysanthemum indicum L., a potential therapeutic agent for obesity and its associated complications. Chrysanthemum indicum L. (C. indicum L.), a member of the Compositae family, is a perennial plant that has been used as a traditional medicine for more than 2000 years in China and is widely used for the treatment of Pemphigus, swelling, pain, and scrofula.
Chrysanthemum extract treatment decreased the activation of NF-κB, IKK, and IKK in LCLs, but intriguingly, it had little to no effect on EBV-negative Burkitt lymphoma cells or human foreskin fibroblast cells, HeLa. Later, it was discovered that lupeol was the substance found in Chrysanthemum extracts, responsible for the anti-lymphoma activity produced by methylene chloride fractionation. The active ingredient in long pepper, piperlongumine, produced a similar outcome by suppressing Myc and NF-κB activities and several downstream target genes; this substance increased apoptosis and decreased cell proliferation in human Burkitt's lymphoma cells, which is a transgenic mouse model.
