N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. ?It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3
N-Eicosanoyl Serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease
1) Yan?et al.?(2018),?Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB; Proc. Natl. Acad. Sci. USA,?115?E12053
2) Asam?et al. (2017),?Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid; PLoS One,?12?e0189413
3) Basurto-Islas?et al.?(2014),?Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease; Neurobiol. Aging,?35?2701
