Description
N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3
References
[1] RUN YAN. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018: E12053-E12062. DOI:
10.1073/pnas.1813365115[2] KESAVA ASAM. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.[J]. PLoS ONE, 2017: e0189413. DOI:
10.1371/journal.pone.0189413[3] GUSTAVO BASURTO-ISLAS . Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease[J]. Neurobiology of Aging, 2014, 35 12: Pages 2701-2712. DOI:
10.1016/j.neurobiolaging.2014.06.012
