General procedure for the synthesis of 6-(trifluoromethoxy)pyridin-3-amine from compound (CAS:1221172-05-9): compound 81 (2.00 g, 9.43 mmol, 1.0 eq.), 10% Pd/C (1.0 g), and ammonium formate (1.2 g, 18.9 mmol, 2.0 eq.) were dissolved in methanol (20 mL) and heated to 55 °C for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filtrate was concentrated to obtain the crude product. The crude product was partitioned between ethyl acetate (100 mL) and 4% NaOH aqueous solution (30 mL) to separate the organic layer. The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to give the target product 82 (1.50 g, 8.38 mmol, 89.4% yield) as a yellow oil.
