KYOTORPHIN

ChEBI: Tyr-Arg is a dipeptide composed of L-tyrosine and L-arginine joined by a peptide linkage. It is a conjugate base of a L-tyrosiniumyl-L-arginine(1+).

Kyotorphin is a neuroactive dipeptide (Tyr-Arg) shown to have analgesic, neuroprotective, and neuromodulatory properties. It is synthesized in nerve terminals and found in the brain and in cerebro-spinal fluid (CSF). Kyotorphin indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). CSF levels are lower in patients with persistent pain and in patients with Alzheimer′s disease.