N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
英文名称:N-Acetyl lysyltyrosylcysteine amide
CAS号:1287585-40-3
分子式:C20H31N5O5S
分子量:453.56
EINECS号:
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE 性质
| 沸点 |
902.5±65.0 °C(Predicted) |
| 密度 |
1.273±0.06 g/cm3(Predicted) |
| 储存条件 |
-20°C, protect from light |
| 酸度系数(pKa) |
9.18±0.10(Predicted) |
| 形态 |
固体 |
| 颜色 |
白色至米白色 |
| InChIKey |
JTHKLTJLEVKKFW-ULQDDVLXSA-N |
| SMILES |
C(N)(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCCN)NC(C)=O |
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE 用途与合成方法
N-Acetyl lysyltyrosylcysteine amide 是一种有效的，可逆的，特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。
N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.
|
Animal Model:
|
8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
|
|
Dosage:
|
10 mg/kg
|
|
Administration:
|
I.p.; daily for 3-7 days
|
|
Result:
|
Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
|
| 更新日期 |
产品编号 |
产品名称 |
CAS号 |
包装 |
价格 |
| 2026-09-15 |
HY-125039 |
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE |
1287585-40-3 |
1 mg |
900 |
| 2026-09-15 |
HY-125039 |
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE |
1287585-40-3 |
5 mg |
2250 |
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE供应商
更多
上海德欣致远生物技术有限公司
联系电话：021-58088081 18317173152
产品介绍：
中文名称：三肽抑制剂
英文名称：N-Acetyl lysyltyrosylcysteine amide
CAS：1287585-40-3
纯度：98%
包装信息：1g;10g;100g
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：N-Acetyl lysyltyrosylcysteine amide
CAS：1287585-40-3
纯度：98.00%
包装信息：1mg;5mg;10mg
备注：试剂级
上海源叶生物科技有限公司
联系电话： 15026964105
产品介绍：
英文名称：N-Acetyl lysyltyrosylcysteine amide
CAS：1287585-40-3
纯度：98%
包装信息：10mg
备注：S33795
上海超岚化工科技中心
联系电话：QQ：65489617 13301690235
产品介绍：
CAS：1287585-40-3
纯度：98
包装信息：1G,5G,10G,50G,100G,500G
备注：仅用于药证申报和科学研究，不为任何个人提供产品和服务
成都云希化工有限公司
联系电话：+86-17380623303
产品介绍：
中文名称：三肽抑制剂
英文名称：N-Acetyl lysyltyrosylcysteine amide
CAS：1287585-40-3
纯度：95%
包装信息：1G; 10G; 100G
备注：企业级
最新发布供应信息
三肽抑制剂
杭州固拓生物科技有限公司
2026-09-30
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