Basic information Safety Related Supplier


Basic information Safety Related Supplier
JC-1 Basic information
  • Product Name:JC-1
  • CAS:3520-43-2
  • MF:C25H27Cl4N4.I
  • MW:652.228
  • EINECS:200-258-5
  • Mol File:3520-43-2.mol
JC-1 Chemical Properties
  • Melting point:275–278 ℃
  • storage temp. room temp
  • solubility Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide
  • form crystals
  • color Deep red
  • λmax514nm
  • Biological ApplicationsDetectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity
  • Major ApplicationLangmuir-Blodgett films; lasing systems; nonlinear optical materials; photographic materials1,
Safety Information
  • WGK Germany 3
  • 10-21
JC-1 Usage And Synthesis
  • DescriptionJC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis. It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry. A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers). JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.
  • UsesA dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc
  • Uses
    The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.
JC-1(3520-43-2)Related Product Information
  • Company Name:Lianyungang City and Rui Technology Co., Ltd. Gold
  • Tel:15162260526
  • Company Name:Beijing Ouhe Technology Co., Ltd
  • Tel:13552068683 010-82967028-
  • Company Name:Nanjing Asian Chemical Co., Ltd.
  • Tel:+86 (25) 82263158
  • Company Name:ShangHai YuanYe Biotechnology Co., Ltd.
  • Tel:15800763013 021-61312847-
  • Company Name:Haoyuan Chemexpress Co., Ltd.
  • Tel:86-21-58998985