Gly-Arg-Gly-Asp-Ser

Gly-Arg-Gly-Asp-Ser has been used-

• as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
• for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1⁺ progenitor cell differentiation into SMCs (smooth muscle cells)
• as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
• for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus

Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.

Antagonist of integrin function