促甲状腺素释放激素游离酸
促甲状腺素释放激素游离酸 性质
| 沸点 | 942.1±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.461±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 3.29±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
促甲状腺素释放激素游离酸 用途与合成方法
促甲状腺素释放激素游离酸外观上呈白色或类白色冻干粉末。
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH)是促甲状腺激素释放激素一种生理代谢产物。TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [ 3 H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na + channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na + current amplitude is reduced by 20-50%.
