Tert-butyl N-[(methylcarbamoyl)methyl]carbamate (300 mg, 1.59 mmol, 1.00 eq.) was dissolved in dichloromethane (5 mL), hydrochloric acid (1.2 mL) was added, and the reaction was stirred for 4 hours at room temperature. After completion of the reaction, the mixture was concentrated under vacuum to give 2-amino-N-methylacetamide hydrochloride (185 mg), the product was a colorless oil. Mass spectrum (MS): m/z 89 (M + H)+. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3): δ 8.45 (br s, 1H), 8.19 (s, 3H), 3.50 (d, 2H), 2.65 (d, 3H).
