BMS 819881, is a potent and highly selective MCHR1 functional antagonist. It has how shown high selectivity towards CYP3A4 activity with an EC50 of 13 μM.
in vivo
BMS-819881 has moderate terminal elimination half-life (t1/2=5.7 h, 32±8 h, and 14±3 h for rat (1 mg/kg, iv), dog (1 mg/kg, iv), and cynomologous monkey (1 mg/kg, iv))[1].
