ADX71743
ADX71743 性质
| 沸点 | 405.1±24.0 °C(Predicted) |
|---|---|
| 密度 | 1.130±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO: 5mg/mL, clear (warmed) |
| 酸度系数(pKa) | -0.05±0.40(Predicted) |
| 形态 | powder |
| 颜色 | white to beige |
| InChIKey | CPKZCQHJDFSOJT-UHFFFAOYSA-N |
| SMILES | CC1=CC(C)=CC=C1C2CC(OC(CC)=N3)=C3C(C2)=O |
ADX71743 用途与合成方法
|
mGlu7
|
ADX71743 has an IC
50
of 300 nM in-house cell lines. Pretreatment of ADX71743 (3 μM; for 20 min) before high-frequency stimulation (HFS) results in an almost complete blockade of LTP induction.
ADX71743 (0.1, 10 μM) reverses L-AP4-induced depression of synaptic transmission and results in a concentration-dependent reversal of the L-AP4-induced depression. 0.1 μM ADX71743 reverses the effects of L-AP4 by 11% and 10 μM results in a 20% reversal.
ADX71743 can against an EC
80
of glutamate (IC
50
of 22 nM) as well as against an EC
80
of L-AP4 (IC
50
of 125 nM).
ADX71743 (50, 100, 150 mg/kg; SC) results in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100 mg/kg).
ADX71743 (12.5, 100 mg/kg for mice and 100 mg/kg for rat; SC) has a T
1/2
of 0.68, 0.40 hours, a C
max
of 1380, 12766 ng/ml of 12.5 mg/kg and 100 mg/kg in mice.
| Animal Model: | Adult male C57Bl6/J mice (24-30 g) |
| Dosage: | 50, 100, 150 mg/kg |
| Administration: | SC |
| Result: | Resulted in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100 mg/kg). |
| Animal Model: | Adult male C57Bl6/J mice (24-30 g) and Sprague-Dawley rats (250-350 g) |
| Dosage: | 12.5, 100 mg/kg for mice and 100 mg/kg for rat (Pharmacokinetic Analysis) |
| Administration: | SC |
| Result: |
Had a T
1/2
of 0.68, 0.40 hours, a C
max
of 1380, 12766 ng/ml of 12.5 mg/kg and 100 mg/kg in mice.
Had a T 1/2 of 1.5 hours, a C max of 16800 ng/ml of 100 mg/kg in rat. |
ADX71743 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-110278 | 1431641-29-0 | 5 mg | 3383 | |
| 2024-08-19 | HY-110278 | 10 mg | 5416 |
