ADX71743

ADX71743 has an IC ₅₀ of 300 nM in-house cell lines. Pretreatment of ADX71743 (3 μM; for 20 min) before high-frequency stimulation (HFS) results in an almost complete blockade of LTP induction.
ADX71743 (0.1, 10 μM) reverses L-AP4-induced depression of synaptic transmission and results in a concentration-dependent reversal of the L-AP4-induced depression. 0.1 μM ADX71743 reverses the effects of L-AP4 by 11% and 10 μM results in a 20% reversal.
ADX71743 can against an EC ₈₀ of glutamate (IC ₅₀ of 22 nM) as well as against an EC ₈₀ of L-AP4 (IC ₅₀ of 125 nM).

ADX71743 (50, 100, 150 mg/kg; SC) results in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100 mg/kg).
ADX71743 (12.5, 100 mg/kg for mice and 100 mg/kg for rat; SC) has a T _1/2 of 0.68, 0.40 hours, a C _max of 1380, 12766 ng/ml of 12.5 mg/kg and 100 mg/kg in mice.